(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol
Benflumetol
CAS: 82186-77-4
Molecular Formula: C30H32Cl3NO
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol - Names and Identifiers
| Name | Benflumetol |
| Synonyms | Benwuchun CPG-56695 benflumetol Benflumetol Lumefantrine Benflumentol BENFLUMETOL (OR LUMEFANTRINE) 2-(dibutylamino)-1-{(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]-9H-fluoren-4-yl}ethanol (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol (9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol (Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-alpha-[(dibutylamino)methyl]-9H-fluorene-4-methanol |
| CAS | 82186-77-4 |
| EINECS | 617-303-4 |
| InChI | InChI=1/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15- |
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol - Physico-chemical Properties
| Molecular Formula | C30H32Cl3NO |
| Molar Mass | 528.94 |
| Density | 1.252 |
| Melting Point | 129-131°C |
| Boling Point | 642.5±55.0 °C(Predicted) |
| Flash Point | 342.3°C |
| Solubility | DMSO: ≥20mg/mL |
| Vapor Presure | 2.2E-17mmHg at 25°C |
| Appearance | powder |
| Color | yellow |
| Merck | 14,5597 |
| pKa | 13.44±0.20(Predicted) |
| Storage Condition | 15-25°C |
| Refractive Index | 1.633 |
| Physical and Chemical Properties | Density 1.252 |
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29221950 |
(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol - Reference Information
| anti-malarial drugs | , it is also the main pharmaceutical ingredient of the well-known antimalarial drug compound artemether of Novartis Pharmaceuticals. It can kill the Anisocytosis of Plasmodium, with a high insecticidal rate of about 95% Recovery Rate, but it is invalid for the prophase of red and gametophyte. The animal experiment is a slightly toxic drug, but the mutagenic and teratogenic tests are negative. Clinically used for the treatment of falciparum malaria, especially for the treatment of chloroquine-resistant falciparum malaria.|
| pharmacokinetics | oral absorption is slow, elimination is also slow, and the residence time in the body is long. After administration, tmax was 4-5H and t1/2 was 24-72H. |
| usage and dosage | 4d therapy: 800mg/day for adult, mg/day for adult; children Daily 8 mg/kg, even for 4d, the first dose doubled, but the first dose of the maximum dose does not exceed 0.6g. |
| adverse reactions | no significant adverse reactions, a small number of patients had mild prolongation of ECG Q ~ T interval. |
| precautions | should be used with caution in patients with heart or renal insufficiency. P. Falciparum malaria patients after symptom control and red phase protozoa can be killed after primaquine gametophytes. Protected from light, sealed, cool and dry place. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
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